The rate of mean platelet volume( MPV) in the blood test. Why is it higher or lower than normal?

Platelets are small, non-nuclear blood platelets that are an essential element in the human body. When damage or integrity of blood vessels occurs, these cells are able to eliminate bleeding through the formation of certain blood clots. This is one of the protective functions that prevent a large loss of blood in the body, which can be dangerous to human life.

Table of contents:
  • Norm
  • Average platelet count above the standard
  • Lowered

Therefore, in modern laboratories determine not only the level and quantity of platelets, but also their state and average platelet volume MPV.It is very difficult for an ordinary patient to understand what the result of the analysis means, so the article is dedicated to those who want to learn to understand the quantitative and qualitative characteristics of their blood.

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Norm

Like other blood parameters, platelets have a framework that is considered the norm for the proper functioning of the body. Thus, it is considered to be

normal for platelets to be from 200 to 400 * 109 / l, and the average volume of erythrocytes( MPV) normally can vary from 7.5 to 11 fL( femtoliter).This indicator is calculated on a hardware analyzer.

It should be noted that during the day the indicator can change by 10%, the level can also be rebuilt depending on the time of day or time of year. It has been observed that at night and in springtime, the platelet count decreases markedly.

The average platelet volume, the norm in women during menstruation is automatically reduced by 20-50%, this is a physiological protective state, therefore, no special measures and treatment is required.

During pregnancy, this indicator also undergoes some changes, as a rule, the average amount of mpv platelets is below normal. However, if the expectant mother’s figure drops to 140 * 109 / l, it is urgent to take measures, since there is a high probability of increased bleeding during childbirth.

So it happens that deviations of the indicator from the norm are minor, and have physiological reasons, for example:

  • period after surgery or surgery and the loss of a certain amount of blood;
  • after receiving multiple wounds, injuries and injuries;
  • in the period of heavy menstruation;
  • in young children who have not yet fully formed the hematopoietic system;
  • taking certain types of medications that stimulate blood formation;
  • sometimes deviations can be associated with heavy physical exertion or a long stay in the highlands.
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Average platelet volume above normal

Increased average platelet volume in some cases can be an alarm and indicate some pathological processes in the body. A person with such an indicator will have to go through several stages of the examination in order to detect what this violation is connected with.

It should be understood that there is a clear inverse relationship between the cellular level and their average volume: if the average volume of platelets in the blood is increased, the number of these cells is reduced.

The following pathologies can serve as causes of the increased volume:

  • diabetes mellitus;
  • thrombocytopenia( platelet count less than 150 * 109 / l, accompanied by increased bleeding and problems with stopping bleeding);
  • spleen enlargement or hypersplenism( accumulation of red blood cells, leukocytes, platelets in the spleen);
  • vascular atherosclerosis( accumulation of cholesterol, fats on the walls of blood vessels, plaque formation and narrowing of the lumen of the arteries);
  • increase in thyroid hormones or teriotoksikoz( occurs due to disruption of the thyroid gland);
  • erythremia, myeloid leukemia and other blood diseases;
  • rare Mei-Hegglin anomaly( inherited, characterized by a decrease in the number of platelets and their insufficient and inadequate formation in the bone marrow);
  • alcoholism and malicious smoking of tobacco.

Average platelet volume increased, what does this mean? Independently interpret the result will not succeed, one increased figure may mean nothing. The specialist must necessarily analyze the remaining blood parameters and, if necessary, refer the patient for additional examination and examination.

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Lowered

When cf.platelet volume is decently lowered, this condition is characterized by poor blood clotting, the risk of extensive bleeding increases, and the healing of wounds and damage to tissues and organs worsens.

The causes of low mean platelet volume in the blood are very diverse, ranging from genetic factors to the presence of various inflammatory processes and diseases in humans, the main ones are:

  • cancer, such as malignant neoplasms and bone marrow;
  • leukemia( leukemia);
  • HIV, rubella, measles, severe influenza affect platelet count and volume;
  • cirrhosis of the spleen or diseases of the spleen( these two organs are responsible for the elimination of old platelets);
  • renal failure or hemodialysis( extrarenal cleansing of the blood with a special "artificial kidney" apparatus);
  • disruption of the thyroid gland or its abnormal functioning leads to a change in the formation of blood platelets;
  • poisoning with heavy metals or bad alcohol.

With a low average platelet volume, patients usually complain of bleeding and bruising, even from small strokes, as well as poor healing of wounds and abrasions. In addition, a person may often have burst capillaries on the retina and small blood bubbles on the body.

Average platelet volume is reduced in a child for the same reasons as in an adult, so the best option for the first suspicion is to consult a doctor.

When blood cells cannot fully perform their work, it threatens a person to deteriorate his health and well-being. Take blood tests regularly and consult a specialist.

Take care of yourself!