Trimedate in irritable bowel syndrome


Irritable Bowel Syndrome


  1. Diet, maintenance of food diary, liquid, not less than, l per day
  2. Restoration of motilit
    y, decreased visceral hypersensitivity. Trimedate 200 mg (1 tablet) 3 times a day for 30 min before meals, 3 - 4 weeks. When a persistent clinical effect is achieved, maintenance therapy with a dose of 100 mg (1/2 tablet) continues 3 times a day for up to 3 months.
  3. Measures aimed at normalizing the intestinal microflora: Within 5-7 days, take one of the intestinal antiseptics (erysefuril 200 mg 4 times a day or furazolidone 100 mg 3 times a day or others) followed by a probiotic during 2 and more weeks.
  4. If constipation is preserved after 5 to 7 days from the start of therapy, lactulose 15-30 ml per day should be used for 2 to 3 weeks
  5. Psychotropic medications according to indications: Terialzhen (alimamazine) 5 mg (1 tablet) at night 2-4 weeks


  1. Diet, keeping a food diary.
  2. Restoration of motility, decreased visceral hypersensitivity. Trimedate 200 mg (1 tablet) 3 times a day for 30 min before meals, 3 - 4 weeks. When a persistent clinical effect is achieved, maintenance therapy with a dose of 100 mg (1/2 tablet) continues 3 times a day for up to 3 months.
  3. Measures aimed at normalization of intestinal microflora.
  4. Bactistatin (antiseptic, prebiotic, intestinal enterosorbent) 1 capsule 2 r. per day for 3 weeks. Since Bactistatin contains an enterosorbent zeolite, additional adsorbents are not required.
  5. Psychotropic medications according to indications: Terialzhen (alimamazine) 5 mg (1 tablet) at night 2-4 weeks

Trimedate ®

effective treatment of pain, colic and spasms,

eliminates the severity in the stomach, nausea,

relieves bloating,

restores regular intestinal peristalsis.

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Excipients:lactose, silicon dioxide colloid, talc, corn starch, magnesium stearate.

10 pieces. - packings of cellular contour (1) - packs cardboard.
10 pieces. - packings cellular planimetric (2) - packs cardboard.
10 pieces. - packings cellular planimetric (3) - packs cardboard.

- gastroesophageal reflux disease;

- motor disorders in functional gastrointestinal diseases;

- Dyspeptic disorders in gastroduodenal diseases (abdominal pain. impaired digestion, nausea, vomiting);

- irritable bowel syndrome, manifested by pain, colic in the abdominal cavity, intestinal spasms, flatulence, diarrhea and / or constipation;

- postoperative paralytic intestinal obstruction;

- Preparation for X-ray / endoscopic examination of the digestive tract;

- dyspeptic disorders in children associated with a violation of the motility of the gastrointestinal tract.

- Children under 3 years of age (for this dosage form);

- Hypersensitivity to the components of the drug.

Adultsandchildren over 12 yearsthe drug is administered orally 100-200 mg 3 times a day. To prevent the recurrence of irritable bowel syndrome after the course of treatment during the remission period, it is recommended to continue taking the drug at a dose of 300 mg / day for 12 weeks.

Children aged 5-12 yearsappoint 50 mg 3 times a day,children aged 3-5 years- 25 mg 3 times / day.

Until now, no cases of an overdose of Trimedate have been reported.

Drug interaction of the drug Trimedate is not described.

Pregnancy and lactemia

It is not recommended to use Trimedat in the first trimester of pregnancy.

It is not recommended to use the drug Trimedat during lactation (breastfeeding) due to the lack of reliable clinical data confirming the safety of the drug.

ATexperimental researchthere was no evidence of teratogenicity and embryotoxicity of the drug.

Rarely:skin reactions.

Terms and conditions of storage

The drug should be stored out of reach of children at a temperature of no higher than 25 C. Shelf life - 3 years.

The course of treatment of irritable bowel syndrome in the acute period of 600 mg / day for 4 weeks and continued treatment after a course of 300 mg / day for 12 weeks to avoid relapse disease.

Application in childhood

The drug in this dosage form is not prescribed for children under 3 years of age

Conditions of leave from pharmacies

Preparation # 17; rimedate # 187; with irritable bowel syndrome

We bring to your attention the material on how to use the drug Trimedat in irritable bowel syndrome. For you, brief descriptions of the symptoms of irritable bowel syndrome, and methods of treating this condition have been prepared. There are various drugs for the treatment of irritable bowel syndrome. Among them, the leading place is occupied by medicines, which have a direct effect on the relief of the pain syndrome.

To date, irritable bowel syndrome has been defined as a polyethiologic disease that occurs with a violation of motility, secretion and visceral sensitivity of the intestine without structural changes in the mucosa shell.

Symptoms of irritable bowel syndrome

The last modernization of criteria for the diagnosis of irritable bowel syndrome was carried out in 2006. in Rome (Roman criteria III). In accordance with this international consensus, irritable bowel syndrome is defined as a complex of functional disorders. The main clinical symptoms of irritable bowel syndrome include abdominal pain or abdominal discomfort at least 3 days per month for the last 3 months. With the onset of symptoms no less than 6 months. before the first visit to a doctor who have at least two of the following three symptoms: a decrease in symptoms after defecation, a change in the frequency and shape of the stool.

Pain syndrome

In any of the variants of irritable bowel syndrome, abdominal pain is an obligatory component. The pain has a wide range of intensity from mild discomfort, tolerable aching pain, to intense cramping pain. Patients with irritable bowel syndrome are characterized by the appearance of pain immediately after eating. Against the background of the appearance of pain, swelling and abdominal distension, increased intestinal peristalsis, and stool changes are noted. The pain subsides, as a rule, after defecation and separation of gases and do not disturb at night.

The basis of the pain syndrome in irritable bowel syndrome is visceral hypersensitivity and intestinal motility disorder. The increase in the sensitivity threshold of the visceral receptors of the intestinal wall determines the perception of pain and motor function of the intestine. In the regulation of the motor function of the intestine, internal innervation by the enteral system predominates, with a high sensitivity to opiate receptors in the central and peripheral structures.

Treatment with Trimedate in irritable bowel syndrome

For treatment, various drugs are used in irritable bowel syndrome. A promising area in the correction of motor bowel disorders in irritable bowel syndrome is the use of synthetic enkephalinergic agonists of opioid receptors. To date, the universal regulator of gastrointestinal motility from the available in the Russian pharmaceutical market is trimebutin (Trimedat, JSC "Valenta Pharmaceuticals") - a complete agonist of all three types of peripheral opioid receptors. The mechanism of its action is to stimulate peripheral enkephalin receptors (μ, κ, δ) throughout the gastrointestinal tract. Binding to k-receptors leads to a decrease in muscle activity, and binding to κ- and δ-receptors causes its stimulation. In this case, the drug does not affect other receptors. Being a total agonist of opioid receptors, trimebutin has a direct effect on smooth muscle cells through receptors on the myocytes and in the ganglions of the enteral system, simulating the action of enkephalins.

In addition, the preparation Trimedat promotes the release of gastrointestinal hormones - motilin, VIP, gastrin and glucagon, which have a prokinetic potential. The action of trimebutin on the visceral sensory afferent nerves can explain its beneficial effect in the treatment of irritable bowel syndrome. The authors of this report have their own experience of using trimebutin at a dose of 600 mg / day. within 1 month. in 30 patients with different variants of irritable bowel syndrome. As a result, a number of conclusions were drawn. Trimedate is an effective treatment for abdominal pain and changes in intestinal function in patients suffering from different versions of irritable bowel syndrome. This confirms the regulatory role of the drug Trimedat in different variants of intestinal motility disorder.

Indications and dosage

Indications for the use of trimebutin are various violations of the motor function of the stomach - reflux-esophagitis, paresis of the stomach and intestines (including number and postoperative), irritable bowel syndrome, as well as pain associated with functional disorders of the gastrointestinal tract and bile excretory ways. Trimebutin is administered in a dose, g 3 times a day. The course of treatment is 3-4 weeks.



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