AST in the blood test
Aspartate aminotransferase( AST, AsAT, AST) is an enzyme necessary for the synthesis of amino acids, the metabolism of useful substances and the structure of cells and tissues. It is produced intracellularly and is located mostly in the myocardium( heart muscle), less in the liver, nervous tissue, kidneys, muscles of the body.
- What is AST in Blood?
- Norm AST in blood
- Blood test abnormalities ASAT
- ALT blood test: what is it?
- Aspartate aminotransferase reduced, what does this mean?
In a healthy person, almost all AST enzymes are found in tissues, their amount in blood is minimal. An increase in AST in a biochemical blood test indicates any disease associated with cell destruction. Moreover, the fact that AST shows its activity not in all organs gives grounds, having received an analysis result that is different from the norm, to immediately assume a narrow circle of states capable of causing this. So, AST in the blood test: what is it, the norm and what conclusions can be drawn from the result, let's talk today.
What is AST in blood analysis?
For blood tests on AST, a selection is made from a vein. The increased value of AST can be a symptom of serious diseases, at the same time, the analysis of this enzyme must be done during treatment to evaluate the results achieved.
The AST indicator in the biochemical blood test is necessary when assessing the following conditions:
- Myocardial infarction;
- Metastasis in tissues;
- Autoimmune Diseases;
- Cirrhosis of the liver.
When is an analysis of AST prescribed?
. Aspartate aminotransferase in
men and women who complain of the following symptoms may be suggested:
- Nausea( up to vomiting);
- Painful feeling of weakness;
- Discomfort and abdominal pain;
- Yellowing of the skin, eye proteins;
- Sharp pain in the heart, extending into the left half of the body;
- Regular appearance of dark urine;
- Clarification of the chair.
Norm AST in blood
The average activity of AST in women is slightly lower than in men. This explains the lower value of AST in women’s blood. There is also a dependence of the AST standard on the age in children younger than 16 years. This is due to the restructuring and the formation of all organs. After birth, AST significantly changes literally by days and weeks. The rate of analysis also depends on the specific laboratory and equipment used.
The accepted optimal AST values are as follows:
From birth: 25-70 units / l;
up to a year: not more than 58 units / l;
1-4 years: not more than 59 units / l;
5-7 years: not more than 48 units / l;
8-13 years: not more than 44 units / l;
13-16 years: not more than 39 units / l;
Norma AST in men should not exceed 41 units per liter;
For most blood tests, AST is normal in women with no more than 31 units per liter. At the same time, during pregnancy, the rate of AsAT in women in the blood decreases by another 10%, but a false increase can occur as a result of AST release into the blood from red blood cells.to contents ↑
Deviations of the blood test ASAT
In addition to diseases, the increase in the analysis can be caused by the lack of preparation of the patient for blood donation. If you want to get a reliable result, consider these rules:
- The day before going to the laboratory, refrain from excessive physical exertion;
- Give up alcohol at least a week before going to a medical facility;
- Acceptance of extraneous drugs, especially such as antibiotics, large amounts of vitamin A, valerian and echinacea in various forms, is undesirable. If you exclude these drugs is not possible, you must inform your medical professional.
- At least half an hour before donating blood for analysis, refrain from smoking.
- The analysis is done in the morning, on an empty stomach, that is, it is recommended to wait 8-12 hours since the last meal.
- In the morning, before donating blood, try to limit yourself from psycho-emotional stress and muscle loads.
But it also happens that all the rules and precautions were followed, and the blood test AST increased. Do not be in a hurry to ascribe to yourself a whole range of diseases, because deviations of the result can also occur in an absolutely healthy person. For example, provoke AST distortion can:
- Lead poisoning;
- Mushroom poisoning;
- Allergy( including medication);
- Intramuscular injections.
ALT blood test: what is it?
ALT is also an enzyme that has the same functions and significance in human life as AST.Most people who want to understand their results of the analysis of blood, it becomes unclear what it is AST in the blood, what is its difference from ALT?
The fact is that AST or aspartate aminotransferase catalyzes the movement and reaction of an amino acid such as aspartate, and ALT favors the movement of another amino acid, alanine. So these terms, which at first sight frighten a person not related to medicine, take a completely understandable meaning: the first part of the word is responsible for the amino acid, the second means the direct function - transfer( transfer) of functional groups and molecules.
The ratio of ALT and AST has a very important diagnostic value and is called the Rytis coefficient, which was given to him in honor of the scientist, thanks to which it has found wide application in the medical community.
RITIS coefficient( AST / ALT)
If ALT or AST deviates from the value from the norm, the Ritis coefficient starts to have a diagnostic value, for a healthy person, its calculation is not necessary.
The essence of the analysis is simple: ALT is mostly found in the liver and rises in the blood when it is destroyed. AST is located, as mentioned above, in the heart muscle, so that by its sharp increase can be judged on heart diseases.
Despite the fact that ALT and AST are not in the same organ, but in a group of tissues, their organ specificity allows for analysis, given the prevailing location.
Thus, with myocardial infarction, AST increases dramatically, deviating from the optimal value by 800–1000%, while ALT increases only by 150–200%.Hepatitis affects the blood completely differently: ALT increases up to a 20-fold increase in the norm, and AST can increase only 2-4 times.
Healthy people have a Rytis coefficient of 0.9-1.8.With a coefficient equal to two or more, it is necessary to conduct a further examination of the heart muscle. If the ratio AST / ALT becomes less than 1, the doctor may suggest destruction of liver cells as a result of hepatitis or cirrhosis.to contents ↑
Aspartate aminotransferase reduced, what does this mean?
The amount of AST enzymes in the blood cannot be too low, since the situation is also considered the norm when AST is not observed in the blood plasma at all. As you can see from the above reference AST values, only the maximum value is adjusted.
Too low an AST value can tell a doctor about vitamin B6 deficiency, which is also involved in enzyme reactions, or extensive liver damage.
AST carries important information about the patient's health and the state of his tissues, but in order to prevent incorrect interpretation of the results, it is necessary not to speculate on your own, but to consult a doctor.
If you still have questions about what AST is in biochemical blood tests or you want to give an opinion on the topic of discussion, leave comments below. Share useful information with friends and family.
God bless you!