Segmental neutrophils

Decrease or increase of segmented neutrophils in the blood may be one of the normal variants or indicate a different scale deviations in the body. Today we will tell you about segmented neutrophils in a blood test and how to understand your blood test.

Table of contents:
  • Norm
  • Causes when segmented neutrophils are elevated
  • Segmented neutrophils in blood are lowered

Neutrophils are the most numerous group of leukocytes, whose main function is to protect the organism from foreign microorganisms, viruses, viruses, viruses, viruses, viruses, viruses, viruses, viruses, viruses, viruses, viruses, viral infections, viruses, viruses, viral viruses, viruses, viruses, viruses, viral infections, viruses, viral viruses, viral viruses, viral infections, viruses, viral viruses, viral infections, viruses, viruses, viral infections, viruses. Neutrophils are produced in the bone marrow and, depending on their maturity, are divided into 6 types:

  1. Myeloblasts

The initial cell formed by the stem cells of the bone marrow and being the basis for further conversion to neutrophils.

  1. Promyelocytes

A large round cell with the same large nucleus, which occupies almost the entire cell volume.

  1. Myelocytes

A regular-shaped cell, smaller than the previous one. It has a core of red-purple color.

  1. Metamyelocytes

The cage has a smaller, more circular shape and a horseshoe-like nucleus.

  1. Columnar neutrophils

Most of the cell is in the cytoplasm, the nucleus in the cell is narrower and uneven in width.

  1. Segmental neutrophils

All that distinguishes this cell from the stab nucleus is the shape of the nucleus and its division into segments, the rest: dimensions, grain size, amount of cytoplasm, the same. However, only these cells from six groups are considered mature, and they are the most among neutrophils.

When the body receives a signal to detect pathogens, mature cells are sent to them and destroyed by phagocytosis: that is, they absorb and process them inside the nucleus. After that, the neutrophil cell dies, which affects their number.

At the same time, the bone marrow begins to produce an increasing number of immature cells, which can also fight an infection or virus, but only in a difficult case.

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As a percentage of the total number of neutrophils, segmented core normally accounts for 40-65%.This figure varies with age. In newborns, it can take the maximum value, then by 1 month the rate drops to a minimum, and forms up to 6-7 years, after which the rate of segmented core in the blood in children coincides with adult indicators.

Sometimes the absolute neutrophil count is taken into account, in this case the rate in the segmented segment blood is 1800-6500 cells per microliter.

In childhood, the level of segmented neutrophils is largely determined by immature immunity, as well as other temporary factors( recently vaccinated, teeth are cut, etc.).But in what cases is a deviation from the segmented nuclear standard in the blood of women, men and children caused by diseases?

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Causes when segmented neutrophils are elevated

A condition in which the number of neutrophils is increased compared with the norm is called neutrophilia or neutrophilia. There are moderate, severe and severe neutrophilia, which differs in the level of cells in the blood.

Segmentoyaderny in the blood can be increased after an infectious disease. The bone marrow produced too many immature cells before the disease was defeated, then they transformed into full-fledged cells and gave such a picture in a blood test. But there are other factors that influence this.

  • Acute bacterial infections;

Appendicitis, ENT diseases, pneumonia, tuberculosis, salpingitis, otitis media, sore throat, sepsis, scarlet fever, cholera, etc.

  • Necrotic states;

Heart attacks, strokes, massive burns, gangrene, etc.

  • Recently vaccinated;
  • Intoxication;

Lead, alcohol or bacterial toxins.

  • Oncological disease.

Raising segmented neutrophils to moderate neutrophilia can be a normal variant and can be explained by emotional or physical stress, as well as by abundant eating before giving blood. To clarify the diagnosis or to confirm the normal state, the results of other tests are necessary.

If segmenta-neutron neutrophils are elevated slightly during pregnancy, this can also be normal.

Segmented neutrophils are elevated in a child when they are born. This is explained by the fact that the transition from the womb of the mother to the outside world is a great stress for the child, and this is one of the reactions to the adaptation to the new environment.

However, the older the child becomes, the more all the reasons for the increase in neutrophils that were described above are applicable to him. If after passing the analysis there is a slight deviation of segmented neutrophils from the norm in children with normal other indicators, you should not worry. Comprehensive examination is necessary only with a significant difference between the result and the accepted norm.

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Segmented neutrophils in blood are lowered

A condition in which the level of neutrophils decreases compared to the norm - neutropenia. There are several forms of it:

  1. Light( the content of segmented neutrophils exceeds 1000 / μl of blood);
  2. Medium( intermediate form between mild and severe);
  3. Heavy( neutrophil count less than 500 / µl blood).

The reasons for this may be the following:

  • Infectious and viral diseases;
  • Acceptance of certain medications;
  • Genetic Predisposition;
  • Anemia;
  • Allergy;
  • Sluggish chronic diseases;
  • Poor ecology;

Minor deviations in the results of segmented neutrophils are usually not a cause for concern. It is important to see a complete picture of the blood test.

God bless you!