Means for normalization of intestinal microflora
General information# 160; Probiotics (eubiotics) are living microorganisms assigned for therapeutic purposes.
# 160; Prebiotics are substances that promote selective stimulation of growth and metabolic activity of bacteria, normally colonizing the large intestine.
# 160; Probiotics can be a monoculture of living microorganisms of various species (eg, Bifidobacterium infantis v. Liberorum, Lactobacillus acidophilus, Streptococcus faecium SF68), and also contain, in addition to bacteria, substances that stimulate their colonizing ability and reproduction. Some preparations contain spores of bacteria (for example, Bacillus cereus strain IP 5832).
# 160; In order for the prebiotic to serve as a selective substrate for growth and / or metabolic activation of one species or a specific group of microorganism species, colonizing the colon, it should not be hydrolyzed by human digestive enzymes and absorbed in the upper parts of the digestive tract tract. Ingredients of nutrition that meet these requirements, often refer to low-molecular carbohydrates. The properties of prebiotics correspond to fructo-oligosaccharides, inulin, galacto-oligosaccharides, lactulose, lactitol. Prebiotics are found in dairy products, corn flakes, cereals, bread, onion, chicory field, garlic, beans, peas, artichoke, asparagus, bananas and many other products.
- Mechanism of action
# 160; It is suggested that probiotics have antagonistic properties against pathogenic microorganisms: they compete for receptors on epithelial cells, for nutrients; capable of secreting substances that inhibit the growth of pathogenic microorganisms (cytokines, oil acid). The administration of probiotics is accompanied by a decrease in the pH of the intestinal contents, including due to growth production of non-pathogenic bacterial species, which is an unfavorable factor for pathogenic species.
# 160; Probiotics can produce lactase, which can be used for lactase deficiency.
# 160; The most promising means for maintaining the normal microbial composition of the gastrointestinal tract are complex preparations containing several species of live lyophilized bacteria microflora. In particular, the three-component complex, which includes, along with Bifidobacterium infantis v. Liberorum and Lactobacillus acidophilus, Streptococcus faecium, ensures the performance of all functions (antimicrobial, digestive, vitamin-forming) normal intestinal microflora all along intestines. The presence of 3 bacterial components, which are synergists, provides a comparison with mono- and bicomponent drugs with higher antagonistic activity against pathogenic and conditionally pathogenic microorganisms and a wider spectrum of enzyme activity, which is especially important for the treatment of digestive disorders in children who are on an artificial feeding.
# 160; Due to the production of the most important substances of natural flora, probiotics provide a longer-term performance of an active physiological role than prebiotics.
# 160; Components that make up probiotics and prebiotics are not absorbed from the intestinal lumen and do not enter the systemic circulation.
#160; 1. Irritable bowel syndrome.
# 160; The combined use of Lactobacillus acidophilus, Bifidobacterium infantis and fructo-oligosaccharides leads to an improvement in the quality of life and a reduction in the incidence of symptoms. Increased gassing in the intestine can cause symptoms in some patients with IBS, and background of probiotics, for example, Lactobacillus, the colonization of the gas-producing flora is reduced (clostridia).
# 160; High effectiveness of IBS with preparations containing Bacillus cereus is noted.
#160; 2. Acute diarrhea.
# 160; The therapeutic or prophylactic effects of probiotics are demonstrated with travelers diarrhea and antibiotic-associated travelers diarrhea and antibiotic-associated diarrhea; pseudomembranous colitis, caused by C. difficile. Lactobacillus normalizes the stool in patients with repeated episodes of diarrhea caused by C. difficile.
#160; 3. Inflammation of the distal parts of the small intestine in patients with inflammatory bowel disease who underwent proctocollectomy (pouchitis).
#160; 4. Syndrome of excess bacterial growth in the small intestine.
#160; 5. Prophylaxis of colon cancer.
# 160; An attractive feature of probiotics and prebiotics is the absence of known contraindications, except for the presence of hypersensitivity to the components of drugs. Their use during pregnancy and lactation is considered safe.
# 160; With the use of modern bifid-containing, lactose-containing drugs, simultaneous chemo-and antibiotic therapy is allowed.
# 160; Under the influence of antacid drugs, neutralization of lactic acid, which is part of some prebiotics, is possible.
# 160; Not identified.
For the prevention of intestinal dysbiosis, folk medicine recommends eating at least two cloves of white garlic daily. Instead, you can consume garlic soup (if you already have problems with the intestines). To make it, you need to peel and cut the potatoes, then boil it until cooked and add a few crushed cloves of garlic to the broth. Duration of treatment: from three to five days in a row.
In addition, to normalize the intestinal microflora you can use apple puree. It is necessary to thoroughly rinse, peel and seed and cut a kilogram of apples, then transfer them to an enamel pot and pour two cups of purified or boiled water. Cook the mixture on a low heat until the apples are ready (they must be cooked and easily crushed with a fork), and then grind them into a gruel and leave under the lid for cooling. Sugar sand in the mixture is not added, but you can add two teaspoons of liquid honey. Use this puree three - four times a day for half a glass.
Also, in order to normalize the intestinal microflora, it is recommended to drink at least one liter of kefir per day. It can be both normal and biocheto.
It is necessary to clean a few young stems of aloe from the skin and put on a water bath three hundred to three hundred and thirty grams of honey. As soon as the honey melts, it should be added to the milled plant in a puree, and then carefully mix the mixture to a homogeneous mass and leave it under the lid for four to five hours. Ready medicine is taken three times a day for one large (table) spoon.
Drink a day at least one glass of fresh cabbage juice (divide this volume into three equal portions and drink through the same interval of time). Duration of treatment: from two to four weeks.
Grind in a coffee grinder to the state of flour dry brewing leaf green tea, then use the finished powder on a half teaspoon three times a day for forty minutes before eating.
Dysbacteriosis is a violation of the microflora of hollow organs and tissues that have a communication with the external environment. Disturbances can affect the composition, quantitative relationships and, as a rule, affect the respiratory tract, skin, mucous membranes, intestines. Most often, the dysbacteriosis affects the gastrointestinal tract.
Presence of normal microflora in organs communicating with the environment provides natural protection of the organism from penetration of pathogenic microorganisms and their reproduction, contributes to the production of vitamins in the intestine, ensures the fulfillment other functions.
Intestinal dysbacteriosis is associated with impaired intestinal microflora, when instead of a normal bacterial flora consisting of lactobacilli, anaerobic streptococci, enterococci, develops putrefactive or fermenting flora, fungal infections uncharacteristic for the gastrointestinal tract. At a dysbacteriosis in an intestine the pathogenic or conditionally pathogenic flora can develop.
Dysbacteriosis is not a disease, but a condition of the body that develops in various diseases, by taking antibiotics, malignant formations in the stomach or large intestine.
- disorders of stool, alternating constipation and diarrhea;
- flatulence, swelling;
- changes in the odor of stool (putrefactive, acidic);
- periodically arising painful sensations in the abdominal region;
- unpleasant taste in the mouth;
- decreased appetite, general weakness, decreased efficiency.
A severe course of dysbiosis can be accompanied by an increase in temperature, the appearance of a copious, watery stool.
The cause of dysbiosis should be identified necessarily, since this condition accompanies other diseases. The most common diseases are diagnosed during general medical examination and general tests. If necessary, endoscopic examination of the gastrointestinal tract, ultrasound of the liver and kidneys, etc.,
To clarify the diagnosis, the following laboratory tests can be assigned:
- bacteriological study of stool for the presence of pathogenic and conditionally pathogenic microorganisms;
- study of feces on a dysbacteriosis under condition of absence of causative agents of intestinal infections.
The following laboratory data indicate the dysbiosis:
- less than 10 cells of bifidobacteria per 1 g;
- the content of more than 10% of atypical escherichia;
- detection of hemolytic microflora;
- increase in the number of opportunistic gram-negative rods, staphylococci more than 104 per 1 g;
- the detection in 1 g of stool of the amount of fungi (candida) is more than 103;
- greatly increased (more than 2х108) or strongly reduced (less than 106) number of E. coli.
Treatment of dysbacteriosis is selected depending on the severity of the disease. With mild illness, treatment can be performed on an outpatient basis, otherwise hospital treatment is necessary. Drugs are selected depending on the underlying disease, which is accompanied by dysbiosis, the results of bacteriological studies.
With easy flow, it is enough to normalize the intestinal microflora, increasing the number of beneficial microorganisms. To achieve a positive lasting effect allows the intake of lactic acidic drinks enriched with lactobacilli, as well as the means that contribute to the normalization of digestion.
Preparations for dysbiosis
For oral administration
Preparations for normalization of intestinal microflora:
- Attapulgite (Neointestopan)
- Hilak Fort
Preparations that normalize intestinal digestion:
Sources: http://mirror.smed.ru/guides/43355, http://vsekey.ru/zdorovie/5773-sredstva-dlya-normalizatsii-mikrofloryi-kishechnika.html, http://www.medrecipe.ru/zabolevanija-kishechnika/127-disbakterioz.html
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