The role of immunomodulators in the treatment of HPV: an overview of the best means

The human papillomavirus (HPV) is one of the most common diseases that can "sleep" in the human body for many years. Once the immunity with HPV is weakened due to various external and internal factors, the virus is activated. In this case, in addition to the main therapeutic treatment, immunomodulators are prescribed.


The virus is characterized by high contagiousness and can have different transmission routes, including domestic and sexual. As a rule, until the moment when HPV is in "anabiosis active therapeutic measures are not carried out, therefore, scientists believe, that immunomodulators provide protection of the organism, allowing to suppress the development of the pathological process and to increase the protective forces organism

Most often, with the activity of HPV, interferon reception is prescribed, but the treatment should be approached very carefully, since the virus is able to mutate and develop atypically.Therefore, before appointing immunomodulators, the doctor conducts a complete immunological examination of the patient.


  • 1Properties of preparations
  • 2Indications for prescription
  • 3Contraindications
  • 4What is prescribed for HPV
    • 4.1Lycopid
    • 4.2Transfer Factor
    • 4.3Interferon
    • 4.4Cordyceps
    • 4.5Derinath
    • 4.6Polyoxidonium
  • 5Conclusion

Properties of preparations


With antiviral therapy, the main focus is on medical products that can enhance the functionality of the immune system. In order to enhance the immune defense of the body, various forms of immunomodulators are used. It can be tablets, ointments, injections, suppositories, gels.

Reception of immunomodulators requires caution, since when helping to fight the virus, they can replace the immune system, which leads to the opposite effect, that is to reduce the natural immune defense.

However, in spite of the fact that immune preparations are effective enough in the treatment of papillomas, complex measures provide for phased therapy:

  • medicamental therapy, which includes the use of antiviral, as well as immune preparations;
  • prompt removal of benign neoplasms;
  • preventive measures to prevent relapse;
  • postherapeutic observation of the patient.

It is important to remember that immunomodulators are not able to cure HPV on their own, they are used together and allow only to increase the immunity of the patient to a certain physiological level, and the fight against HPV is necessary for all ways.

Indications for prescription


As for any medication, there are contraindications and indications for the appointment of immunomodulators.

Such preparations are shown when:

  • the presence of a slow chronic process in the patient's body;
  • immunodeficiency;
  • tumoral neoplasms;
  • acute development of an allergic reaction.

Immune drugs are conventionally divided into immunomodulators and immunosuppressants. It should be borne in mind that in cases of autoimmune diseases (systemic lupus erythematosus, vasculitis), the use of immunosuppressants (timopressin, Azathioprine and others) is recommended. The action of these drugs is aimed at suppressing the natural immune defense and its replacement with synthetic drugs, in contrast to immunomodulators, which strengthen their own immunity for further infection.


Immunosuppressants are prohibited for use in the following cases:

  • development of diabetes, rheumatoid arthritis;
  • disorders in the thyroid gland, glomerulonephritis;
  • development of multiple sclerosis, myasthenia gravis;
  • hepatitis autoimmune form, systemic lupus erythematosus;
  • asthmatic syndrome.

The use of immunomodulators in these diseases can provoke an increase in negative symptoms and lead to serious complications.

What is prescribed for HPV

At the moment, the most popular immunomodulators in order to increase the immune defense in HPV are:


This potent agent is recommended for use in chronic and slow infectious inflammatory processes of different localization and etiology. In addition, Lycopida can be used in pediatric practice.

Transfer Factor

This immunomodulator is considered to be the most safe and powerful among all drugs in this group. He does not have side effects.


The drug is available in the form of injections, rectal suppositories and powders, but it is contraindicated in the presence of a patient with an allergy. Interferon refers to the protein immunomodulators of antiviral and antitumor effects.


The drug effectively regulates the immune system, while possessing the ability to eliminate genetic failures in the body.


This powerful immunomodulator, which purposefully affects the immune system, strengthening the anti-inflammatory and wound healing effects. Derinat is allowed to be used in pediatric practice.


This drug normalizes the functionality of the immune system in any viral immunological diseases.

Polyoxidonium effectively removes toxins from the body and is allowed for use in pediatrics and without a prior immunological examination.

In addition to pharmacological drugs, in the treatment of HPV immunomodulators of natural origin are actively used, which are capable of affecting the immune defense of the organism at the level of DNA, mobilizing its own immune ability.

The plant immunomodulators include:

  • Wobenzym;
  • Cycloferon;
  • Viferon;
  • Imiquimod;
  • Indinol;
  • Alpisarin.

Vegetable immunopreparations are usually prescribed for any complex therapy involving the use of antiviral, antifungal drugs, as well as antibiotics.

To improve immunity, homeopathic immunomodulators are often prescribed in the form of tinctures and extracts from herbal preparations.

Most often used are:

  • levzeya, aralia;
  • Chinese magnolia vine, echinacea;
  • root of ginseng, eleutherococcus;
  • pink rhodiola, honey;
  • eucalyptus, garlic;
  • aloe, aralia;
  • root elecampane, thyme, walnut, etc.

Recently, in the treatment of HPV, effective immunomodulating agents of combined action are actively used, for example, Medorrinum, Tui Occidentalis, Antimonium krudum. The active substances of these drugs are plant components, which have a milder effect on the body than synthetic drugs.



Immunomodulators for the treatment of papillomavirus can raise the effectiveness of the natural defenses of the body, so that it can independently resist the virus. The result of this interaction is the complete neutralization of the virus and negative manifestations on the skin.

It should be borne in mind that the immunomodulators that are involved in the fight against HPV are clinically verified, but even complete disappearance symptoms of the disease does not give 100% guarantee that the virus is destroyed, and the virus carrier is no longer a danger to the surrounding. After the treatment, HPV can "quiet down" for a while and appear at the most inopportune moment.

Therefore, when a HPV occurs before and after therapy, the PCR procedure (polymer chain reaction) by means of which the presence of viruses in the patient's body is revealed even in the state of immune tranquility.

It is important to remember that even the absence of a characteristic symptomatology of the disease is not an indicator that the patient is not a carrier of the virus.

Despite the positive effect of immunomodulators, there is no consensus among experts on the need for their use. Some believe that such remedies should necessarily be included in the general course of therapy, as they help contain the virus. Others argue that such drugs have a strong strain on the immune system, while not exerting a strong effect on viruses.

The only correct solution for the patient in this situation is consultation with a highly qualified a specialist who will help get rid of papillomas, taking into account the characteristics of the body and the immune status system.

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