How to take Nitroxoline with cystitis
Cystitis (both acute and chronic) is a very unpleasant disease. It is accompanied by pain over the bosom, in the projection of the perineum, frequent and painful urination, changes in the analysis of urine.
Women are sick by 25% - 35% more often because of their anatomy. It is established that 30% of women have at least once had cystitis. In the treatment of inflammatory diseases of the urinary system, many pharmacological drugs are prescribed, including Nitroxoline.
If you get sick
First of all, if you have the above symptoms, consult a urologist or gynecologist.
You will have to take:
- urinalysis (general, according to Nechiporenko);
- swabs from the genitourinary tract;
- study of vaginal discharge or urethra for the presence of pathogenic microflora and its sensitivity to antibiotics;
- bacteriological culture of urine;
- blood for infections that are transmitted with unprotected intercourse.
One of the drugs of choice of treatment for cystitis is Nitroxoline - non-fluorinated quinolone, which was synthesized in the 60's. last century. Nitroxoline has a bactericidal and bacteriostatic effect and belongs to the group of antimicrobial drugs, although it is not an antibiotic.
Getting into the pathogenic microorganism, the Nitroxoline molecule binds the enzyme, which is responsible for the synthesis of DNA bacteria and is embedded in its genome. Thus, pathogens can not multiply and complete their cycle of life - they die. The drug is excreted from the body with urine unchanged.
When is the medicine needed?
Nitroxoline is prescribed not only for acute or chronic cystitis, but for other diseases of the genitourinary system:
- acute and chronic pyelonephritis;
- with catheter infections (when the Foley catheter is standing for urine outflow or epicystostomy is applied).
Contraindications for the use of Nitroxoline are:
- severe chronic liver disease;
- acute and chronic lesions of the kidneys in the oliguria stage (little urine) or anuria (urine is not produced by the body);
- inflammatory diseases of the nervous system;
- the period of pregnancy and the period of breastfeeding (lactation);
- hemolytic anemia;
- personal susceptibility to the components of the drug.
Side effects of taking medication are manifested:
- nausea, vomiting;
- a rash on the body;
- edema of the mucous membranes;
- neurological symptoms (reduction of muscle strength, etc.);
- episodes of loss of consciousness;
- decreased appetite;
- heart palpitations.
The appearance of these symptoms should alert the patient. Do not take any more medication and contact your doctor. Expressed clinical signs - an occasion to address in a reception rest of the nearest hospital.
Nitroxoline in cystitis is effective against many pathogens:
- E. coli;
- gonococcal neisseria;
- diphtheria bacillus;
- Mycobacterium tuberculosis;
- Fungal infections (candidiasis, dermatophytes and mold fungi).
It should be noted that there are microorganisms with 95% resistance to the drug. Therefore, the treatment of infections caused by this kind will be ineffective and requires the selection of another medication. According to the literature, resistant (insensitive) organisms are most often E. coli.
There is still no evidence of teratogenic (causing fetal developmental defects) of Nitroxoline. Experience accumulated by more than one generation of gynecologists, indicates the possibility of using the drug in pregnant women, but have not yet conducted multicenter formal research, this information should be treated with caution.
The prescription of the drug during breastfeeding is also possible, but then it should be transferred to artificial feeding (mixture).
Among patients taking Nitroxolin, positive reviews are received in 90% of cases.
At a doctor's appointment, do not forget to tell us about other medications. Nitroxoline interacts with some groups. Antacids (Maalox, Fosfalugel, Almagel, etc.) reduce its effectiveness, and antibiotics (levorin, nystatin, doxycycline, etc.) increase. In this regard, a competent correction of the dosage of the drug is necessary. Nitroxoline can not be administered together with furadonin, furagin, furazolidone, since the harmful effect on the nervous system increases.
Remember, when using any medication, you should completely eliminate alcoholic beverages. There is evidence of a joint destructive effect of Nitroxoline and ethyl alcohol on the liver of patients. Fortunately, these cases are rare.
What does the drug look like and how to take it?
Nitroxoline is available in tablets of yellow color of 50 mg, in packages can be from 10 to 100 pieces. The basic active ingredient is represented by nitroxoline, and the auxiliary substances: lactose, potato and corn starch, talc, salts magnesium and silicon colloid, sand sugar, Povidone-25, titanium salts, gelatin food, Macrogol 6000, Tropeolin O, red acid dye.
The standard dosage of an adult patient with acute cystitis is 100 mg 4 times a day from 8 days to 15 days. Chronic course of the disease requires increasing the daily dose to 1000 mg (20 tablets per day). The total duration can be up to six months according to the scheme: three weeks taking nitroxoline, two weeks break, then the cycle repeats.
For children, the drug is administered according to the following scheme: from 10 mg to 30 mg per kilogram per day. If your child does not have severe diseases of the renal and hepatic system, standard instructions have been developed, in which you do not need to count the dosage:
- to children under 5 years of age, 200 mg 4 times a day in equal doses;
- from 5 years and up to 15 - 200 mg - 400 mg 4 times a day in equal portions;
- more than 15 years of age - dose as an adult.
Against the background of Nitroxoline, the color of biological fluids (saliva, urine, sweat) changes, in men sperm, in women vaginal discharge. They acquire a bright yellow, sometimes reddish shade. This is normal and not dangerous, as soon as the entire drug is removed from the body, the color of discharge will become normal.
The cost of treatment for acute cystitis in an adult is about 4000 - 5000 rubles, with chronic - about 72 000 rubles.
Take medication is necessary during food, the pill should be taken with 2 - 3 sips of clean water.
Duration of admission depends on the symptoms of the disease and the results of control tests. Continue taking the drug until the urine and smears are normalized from the vagina and urethra (urethra). The disappearance of clinical symptoms is not a sign of a complete recovery.
The drug is dispensed from pharmacies on the prescription of a doctor. Remember, do not get rid of cystitis alone, it can lead not only to the transition of an acute illness to chronic, but cause serious damage to health.