What is dangerous for a man is normozoospermia with aggregation


Table of contents

  • Manifestations of aggregation
  • Causes of agglutination and aggregation
  • Diagnostic measures
  • Ability to conceive during aggregation and agglutination of spermatozoa
  • Plan of action of the doctor
  • Conclusion, conclusions, recommendations

Nowadays the issue of male or female infertility is of great importance. It is known that so many couples can not conceive a child. Infertility in men is about 50% of all cases of inability to conceive a child. There can be very many reasons for this. If in normal medical practice, to establish the diagnosis of an infectious disease, laboratory analyzes of blood, urine, various discharge of the patient, then to determine the sexual function in men the greatest value is spermogram. It is a laboratory analysis of the male's semen fluid, which is conducted to determine its fertility.

Results spermogrammy can be very diverse. There may be a decrease in the mobility of male sex cells, a decrease in the amount of ejaculate, a small amount of active spermatozoa. In some cases, the result of spermogram is normal. This is called normozoospermia. A similar result indicates a normal quality of sperm and an opportunity for fertilization. Sometimes normozoospermia can be combined with aggregation of sex cells. Let's consider in more detail, under what circumstances there is a normozoospermia with aggregation, what is the etiology and therapeutic measures.


Manifestations of aggregation

What is the aggregation (agglutination) of spermatozoa? Two of these concepts are somewhat different. This is important to know. Agglutination involves the process of gluing the sex cells. In this case, spermatozoa are able to connect with each other in different areas: heads, tails, necks. Normally this does not happen. Thus, agglutination is a pathological condition that can reduce the chances of fertilization, despite the normal parameters of the spermogram. If we talk about the sex cells of a man, then they should normally be repelled from each other. This process is provided by a charge, which in all sperm cells is negative. It is known that particles of the same name repel each other.

All this is an adaptive mechanism for providing the best mobility of cells.As for aggregation, this process is characterized by gluing spermatozoa with epithelial cells, mucus particles and other substances.If in the first case the main etiological factor is associated with immune disorders, then the aggregation is determined by the presence of mucous contents in the seminal fluid. In most cases, aggregation does not reduce a man's fertility and does not cause fear. But this condition requires close monitoring.

Causes of agglutination and aggregation

Normospermia with aggregation or agglutination can be observed for several reasons. In agglutination the greatest role is played by immunological shifts, during which antispermic components (antibodies) are found on the surface of spermatozoa. These antibodies promote the gluing of cells, reduce their motor activity. The main cause is a violation of the hematotestick barrier. As a result of such a violation, spermatozoa begin to be perceived by the cells of the immune system as foreign agents, and antibodies begin to move toward the site of their localization.


Antibodies, which are located around the spermatozoa, are components of protein nature. Violation of the hematotestick barrier is observed in various diseases of the genital organs. The most important is prostatitis, inflammation of the testicles, orchitis, as well as traumatic damage testicles. Normospermia with aggregation is observed in case of an increase in the period of dilution of seminal fluid. Etiology is largely related to the presence of foci of chronic infection. This can be a chronic form of epididymitis, prostatitis and inflammation of the vas deferens. Do not forget about sexually transmitted infections.

Diagnostic measures

The presence of aggregation or agglutination is determined using a spermogram and a so-called MAR test.

The latter must be performed before the spermogram. Normozoospermia with aggregation is based on these two analyzes. MAR-test assumes an estimation of mobility of spermatozoa. The proportion of those cells that carry antisperm antibodies is determined. These cells can not perform their basic function, despite the fact that the sperm can show normal results. The test is carried out as follows: a droplet of a special substance is added to the drop of the seminal fluid to be examined. It is a suspension of silicone particles.

It is interesting that these particles are capable of interacting with human antibodies. If the introduced particles bind to male germ cells, this indicates the presence of antisperm antibodies. A similar decision is made based on the total number of bound cells. If they are 50% or more, then antispermal bodies take place. It is agglutination that is the manifestation of the presence of these antibodies. Aggregation, on the other hand, is of lesser diagnostic value, since with it the fertilization function is preserved, and it does not pose a great danger. The spermogram is performed after the test. With it, normozoospermia can be revealed.

Ability to conceive during aggregation and agglutination of spermatozoa

In the presence of agglutination, antisperm antibodies can cause infertility in men. In this case, infertility has an immune nature. As for aggregation, the ability to conceive is preserved with it. When aggregated, male sex cells can accumulate in large numbers, and large strands can be observed. Of definite importance is the fact that during agglutination the sex cells themselves can be damaged. As a result, their morphological characteristics are violated, all this can give negative results after fertilization. It is known that for a normal development of a child, only one fertilization is not enough.


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It is necessary that the genetic material is intact. In this situation there is a certain risk. In this case, the child may develop some deviations during his embryogenesis. Therefore, doctors strongly recommend to abstain for a while from fertilization and to carry out a number of medical measures to normalize the sperm state, while reducing agglutination and aggregation.

Plan of action of the doctor

If a man has a normosoospermia with aggregation or agglutination as a result of spermogram and MAR-test, then first of all it is necessary to eliminate the cause. In most cases, the etiology is associated with the pathology of the genital organs. It can be an inflammation of the appendages, the testes themselves or the vas deferens. Most often, antibacterial agents are used for treatment. The most effective drugs are a group of fluoroquinolones, tetracyclines, macrolides. The course of treatment is appointed by the doctor individually. Equally important for the elimination of this disease is rational nutrition and vitamin therapy. The most important is vitamin C and some microelements, for example, zinc, phosphorus.

To this end, you need to eat more fresh fruits and vegetables, berries, nuts. There are also people's means of help in this situation. They include the use of various infusions and decoctions. The most effective infusions are based on goritsvet, adamic root. You can use tea rose syrup. If there is normozoospermia with agglutination, then filtering methods for cleaning the seminal fluid are used for fertilization. If they do not give a positive result, then use intrauterine insemination. It involves the introduction of purified male sex cells immediately into the uterine cavity. Less commonly, in vitro fertilization.

Conclusion, conclusions, recommendations

Thus, the detection of normozoospermia with aggregation after spermogram and MAR-test does not mean infertility in men. This condition in most cases does not cause difficulties in fertilization, which can not be said about agglutination. This is a more dangerous condition, in which there is a high risk of inability to fertilize. Even with a successful outcome, there is a possibility of complications during fetal development. This process is at the genetic level, and it is impossible to prevent it.


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The thing is that antibodies can disrupt the morphology of spermatozoa, which affects their genetic material. To normozoospermia with aggregation was not detected, it is necessary to lead a healthy lifestyle, eat right. The timely diagnosis and treatment of inflammatory diseases of the genital organs is of great importance.