Why does MCHC increase in the blood test? Reasons and what to do

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Blood test

When carrying out a general blood test, modern laboratories use an automatic system to count uniform elements and various cellular indices. This allows you to make the study more accurate, and the result obtained is used to establish a specific diagnosis. This opportunity appeared not so long ago: abroad the device was used from the end of the 50s, in the CIS countries no more than 20 years.

Platelets, leukocytes and red blood cells have specific indices. Red blood cells, as the red blood cells also call, have four. One of them is MCHC, in English translation "average hemoglobin concentration in erythrocyte". The indicator is specific, it allows to suspect a number of diseases. Why the average concentration of hemoglobin in the erythrocyte is increased, we will tell in this article.

Hemoglobin molecule


  • What is MCHC, as determined, normal values
  • Causes of an increase in MCHC in a blood test
    • The differences between MCHC and MCH
  • Interpretation of the analysis, additional studies, principles of treatment and prevention

What is MCHC, as determined, normal values

MCHC is the average concentration of hb in erythrocytes. It reflects the degree of saturation of all red cells of the body with hemoglobin. The molecule of hemoglobin is a complex substance, it consists of the protein part and iron. Its main function is transport, it carries oxygen, saturating the organs and tissues.

When iron deficiency in the body develops hypoxia - oxygen starvation. In a healthy adult body, the described index is stable and has a constant value. The range in the blood of mchc in children is wider, which is connected with the formation of the hemopoietic system.

Erythrocyte Indexes

To study mchc in a blood test, a capillary blood sampling, that is, a finger, is performed. To get the right result, you must follow a few simple rules:

  1. The analysis is given on an empty stomach, the minimum break between meals should be 8-10 hours.
  2. Before the test, you can drink plain water.
  3. Refuse from smoking, drinking, active sports should be at least a day before the analysis.

The indicator is calculated by a special formula. It is necessary to separate hemoglobin (g / l) * 100 into a hematocrit. The measurement is carried out in grams / liter (g / l). The values ​​of the norm are:

  • 320-365 g / l for men;
  • 320-355 g / l in women;
  • up to 380 g / l in children under 5 years old.
MCHC: calculation formula, blood norm

Laboratories often use an average value for people of both sexes, it is 320-380 g / l. In addition to children, the indicator varies somewhat among the elderly. They are characterized by a decrease in it, which is associated with a decrease in bone marrow activity. This means a decrease in the number of erythrocytes and their indices.

To learn more about MCHC, watch the video below:

Causes of an increase in MCHC in a blood test

Causes that can increase the value of MCHC, a lot. But do not forget about the so-called false positive high level. It can provoke:

  • violation of the rules of blood sampling;
  • violation of material transportation;
  • improper blood storage (high or low temperature, free oxygen access);
  • violation of the rules for preparing for the analysis (they are discussed above).

Remember! A single increase in the average concentration of HB in erythrocytes requires a repeated analysis in dynamics and can not be evidence of the course of pathological processes in the body.


If nevertheless MCHC in the analysis of a blood is raised repeatedly, it is necessary to assume:

  • Hereditary hemolytic anemia: spherocytosis (Minkowski-Schoffar's disease), ovalocytosis. It is with this pathology that MCHC can be maximized. Due to a disruption in the structure of the cell membrane, the deficit of specific proteins of the "skeleton" of the cell (spectrin and ankirin), the function of the erythrocyte suffers. Passage through the spleen causes an intensified destruction (decay) of the cell, dramatically shortening its life span.
  • The pronounced deficiency of vitamins, namely B-12 and folic acid.
  • Chronic hypoxia (as an option - living in the highlands).
  • Oncological pathology, especially hematopoiesis. The bone marrow is involved in the pathological process. There is an oppression of the synthesis of normal cells and an increased formation of cells from the pathological clone.
  • Water-electrolyte imbalance. It is provoked by poisoning, intestinal infections. Abundant vomiting and frequent loose stools are the causes, because of which MCHC in the blood test rises.
  • Diseases of the endocrine system (type 2 diabetes, decreased thyroid function).
  • Sclerotic processes in the lungs, in which there is an oxygen deficiency.
  • Chronic kidney failure.
Minkowski-Schoffar's disease, spherocytes

An increase in the average concentration of hemoglobin in the blood may be temporary. To the means having a raising effect, it is necessary to carry contraceptive, hormonal, some sedative and vasoconstrictive preparations. In any case, if mchc is elevated, you should consult a doctor and undergo a complete examination.

Remember! Tobacco smoking also leads to an increase in this index.

The differences between MCHC and MCH

MCH is the mean content of hb in the erythrocyte. This index reflects the average amount of hemoglobin in one particular cell. It is obtained by dividing hemoglobin by the number of erythrocytes. Counting is done in picograms (pg). The average normal value of mch in a blood test is 24-34 pg. In the diagnosis of children use age standards. If the average hemoglobin content in the erythrocyte is increased, a proportional increase in mchc should be expected. These two values ​​are interrelated and complement each other in the blood analysis.

The normal values ​​of MCH

Interpretation of the analysis, additional studies, principles of treatment and prevention

Assess the analysis should be a specialist. It can be a doctor-hematologist, dealing specifically with blood diseases, or a therapist. In case the diagnosis should be clarified to the child, you need to contact the pediatrician. To establish a diagnosis, a specialist will need:

  • Collect complaints.
  • Assess the clinical symptoms of the disease.
  • To study not only individual erythrocyte indices, but a fully developed blood test, which includes the counting of erythrocytes, leukocytes, platelets, ESR, reticulocytes, indices of these cells.
  • Carry out a biochemical blood test. It is necessary to evaluate the functions of the liver, kidneys, pancreas. The analysis will allow to learn, whether there are inflammatory processes in an organism.
  • Assign instrumental diagnosis, if necessary (ultrasound of the abdominal cavity and kidneys, chest radiography).

After establishing the correct diagnosis, a therapy will be prescribed. Only a doctor should prescribe drugs and give advice on treatment. Assignable drugs can belong to completely different groups, depending on the causes that caused the pathological process.


Attention! A true increase in MCHC is extremely rare. Any self-treatment can cause serious damage to health!


The patient can independently prevent blood diseases and other systems. To do this, it is recommended to follow the principles of proper nutrition, exercise regularly, spend time in the open air, limit the consumption of alcoholic beverages and reduce the number of cigarettes. These measures will improve the exchange of oxygen and prevent the development of diseases.

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