Parameters of plasminogen in the blood test, which means excess and lower levels?

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2017.09.15
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Blood test

Plasminogen is one of the most important blood proteins, which turns into plasmin. The latter, in turn, plays a major role in the fibrinolytic system. This ability of blood to dissolve blood clots is a vital process that should function normally at all times. Therefore, for serious diseases, an analysis is made, with the help of which the given blood capacity is evaluated.

Scheme of conversion of plasminogen to plasmin

Content

  • Fibrinolytic system of blood
  • Preparation for diagnosis
  • What should be the parameters of plasminogen?
  • When is the plasminogen index higher or lower than normal?

Fibrinolytic system of blood

This process - the antagonist of blood sedimentation, when blood cells lose their mobility and settle on the walls of blood vessels, subsequently thrombi can form. Under the influence of the fibrinolytic system, the protein thrombus collapses. In this case, the enzyme plasmin acts on it.

When blood clotting passes without disturbances, plasminogen in an inactive state is in the blood vessels. It is activated by special enzymes (plasminogen activators). When the fibrin clot dissolves, normal blood flow is restored.

Plasminogen is activated by two types of activators:

  • Tissue - always in the body in the active state. It is released when the integrity of tissues or organs is damaged;
  • Urokinase - is produced in the kidneys, so sometimes occurs in the urine, this is indicated by its fibrinolytic activity.

Both the first and second activator are important for the normal functioning of the fibrinolytic system.

Even in the body there are substances with the opposite action - inhibitors. They suppress the activators, as a result of which blood clotting is resumed. Scientists have invented artificial inhibitors, they are used in cases of severe internal or external bleeding.

Preparation for diagnosis

Special preparation for delivery of the analysis is not required. Do not have to adhere to a special diet or exclude from the diet of certain foods.

The attending physician who prescribes this study should know which medications the patient is taking. And if they can affect the results of the study, the doctor can temporarily stop taking medication. Some time after the procedure, the patient is allowed to continue taking medication.

For examination, the material is taken by puncture of the vein. Initially, sodium citrate is poured into a test tube and blood is poured into it. On the place where they made a puncture, they put a cotton ball to stop the bleeding. There is a table with which to compare the obtained data to determine the level of protein - within the norm or not.

Biomaterial sampling technology standard

What should be the parameters of plasminogen?

Normally in an adult human globulin activity in the blood is 80 - 135%. In newborns, the percentage is much lower than for adults, and the rate is 60%.

When is the plasminogen index higher or lower than normal?

Plasminogen is elevated in serious diseases, and its index may exceed the norm during the postoperative period, especially if the intervention was difficult. Most often this condition of the blood is diagnosed:

  • with pancreatitis and pancreatic necrosis;
  • if melanoma develops in the body;
  • with oncological diseases of the prostate and ovaries;
  • as a consequence of treatment of diseases of the pancreas, prostate and lungs, if the treatment was performed surgically;
  • with ICE;
  • when serious liver diseases are diagnosed;
  • with hypertensive crisis.

Plasminogen is often elevated in pregnancy, this is one of the physiological causes of this condition. All because in the body of the future mother there is a number of changes already in the first weeks. The fruit for normal growth and development requires micronutrients and other substances that it receives from the mother's body. Therefore, a number of violations and changes are often diagnosed in women during this period. After giving birth, the body is restored, and all the indicators come back to normal.

Plasminogen during pregnancy can be high and low. It all depends on the period of pregnancy. In the third trimester, the rate may rise to 165%. This can be dangerous for the future mother and baby and adversely affect the delivery process, especially if a planned cesarean section is planned. It is necessary to do a regular blood test and to examine this indicator.

An interesting situation affects the parameters of plasminogen

Low plasminogen (reduced activity) is diagnosed in very rare cases. Usually this pathology is transmitted from mother to child. In this case, protein deficiency can lead to the development of a thrombus. When the level of plasminogen is lowered, the activity of the antigen does not exceed the limits of the norm.

There are diseases that can provoke such a condition. These are severe hepatocellular diseases, when malignant liver tumors develop. When treating various pathologies with the enzyme streptominase or urokinase, the risk of a drop in the level of this protein in the blood also increases.

Quickly and qualitatively you can do a blood test in the Invitro laboratory. Further it is necessary to consult with the doctor so that he will study the results and make a conclusion.

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