Candida meningitis is a disease in which the membranes of the brain and spinal cord become inflamed. Called fungi of the genus Candida. The disease is rare, usually it affects premature newborn babies. Sometimes they become infected with patients who have undergone neurosurgical shunt operations. If the disease affects the immunocompetent person, then the course of the disease is extremely aggressive.
- Causes of candidal meningitis
Causes of candidal meningitis
Pathology refers to endogenous (internal) infections. Candida fungi are always present in the body in a small amount, under certain conditions they begin to multiply actively.
Pathology can develop in two ways:
- During the disease, pathogens already in the body begin to multiply, as the immune system of the patient is significantly reduced. They can be localized on the mucous membranes of the mouth, intestines, skin. Then penetrate into the internal organs, through the lymphatic or circulatory system damage the cerebrospinal fluid, cerebral vessels. The disease worsens the patient's plight.
- The second variant of penetration of the infection into the body is a venous catheter. Pathogens get to the catheter through the skin of the patient himself or through the hands of medical personnel.
The most common in Africa, but it records in all states, mainly among toddlers up to five years old.
Perhaps the development of the disease in acute and chronic form. The patient's temperature rises to 38 degrees (there is no possible candidal meningitis without fever). The person is apathetic, languid and inactive. Often patients complain of headaches, dizziness. They are disturbed by the work of the senses - sight, hearing, and smell are deteriorating. Possible vomiting fountain, shortness of breath, respiratory failure, increased palpitations.
Skin covers are covered with hemorrhagic rash. Patients begin to rave, confusion manifests. The upper and lower limbs become less sensitive, full or partial paralysis is possible.
Manifestations do not seem to be eithersystemicorInvasive Candidiasis!
The first reception of patients is performed by a therapist or surgeon in a hospital. If we are talking about children, then the pediatrician. The doctor examines the patient, examines the symptoms, prescribes the necessary tests. Then patients are delivered to the intensive care unit or intensive care unit or neurological department, depending on the condition. Then they are observed by an anesthesiologist, neuropathologist and neurosurgeon. After receiving accurate results of the tests, the treatment is complemented by an infectious disease specialist.
The necessary laboratory research includes the following:
- a general blood test, which is characterized by a sharp increase in leukocytes, shifting the leukocyte formula to the left and a significant increase in the level of ESR. These indicators indicate that the body is undergoing a serious inflammatory process;
- the general analysis of urine - in it the level of leucocytes and cells of a flat epithelium will be raised;
- analysis of cerebrospinal fluid. This is one of the main tests, which accurately indicates candidal meningitis.
The fluid is taken with a special puncture needle. If you suspect a disease, it becomes cloudy, opaque. Significantly increased the amount of protein (from 1000 to 16000 at a rate of up to 330). Cytosis (the number of cells in 1 μl) is from 250 to 700 units, with a norm of 2 to 8. In the liquid, a fibrin film is formed.
In addition, serological studies of blood serum and microscopic examination of cerebrospinal fluid are carried out. Based on all the tests, the doctor diagnoses candidal meningitis.
Therapy is appointed after the candida fungi have been found in the cerebrospinal fluid. Treatment is carried out with antimycotic drugs. Dosage is selected by the doctor, based on the patient's condition and body weight.
As antifungal agents are appointed "Fluconazole"(From 400 to 800 mg)Medoflucon Amphotericin B liposomal" Amphotericin B ". Treatment takes a long time, at least four weeks after all the symptoms disappear. Therapy includes the removal of foreign bodies from the body: catheters, shunts. After treatment, the analysis of cerebrospinal fluid should be completely satisfactory.
In case of increased intracranial pressure or starting brain edema, diuretics are prescribed (eg Furosemide). Treatment can be corrected by other doctors, based on the underlying disease..
Candida meningitis is a serious and dangerous disease. Any self-treatment is contraindicated. Traditional medicine is powerless in the fight, since fungi are localized on the internal organs, in the blood, on the membranes of the brain and spinal cord..
Candidial meningitis is usually a concomitant disease. Against the background of a weakened organism, a lethal outcome often occurs. It is observed in 85% of cases of recorded diseases. Even with full recovery, a person becomes disabled and gets a disability.
The disease can be complicated by hydrocephalus, cerebral edema, epilepsy, a disorder personality, deafness, blindness, paralysis, acute adrenal insufficiency, infectious-toxic shock.
People at high risk are prescribed fluconazole orRumikosis from fungus, as a preventive agent.
In the case when the risk of getting sick is not high, then the intake of antifungal drugs is unfounded. This can be dangerous for the patient himself, as it leads to the fact that candida fungi become resistant to antimycotic drugs, the selection of new strains Candida.
The general measures of prevention include enhancing the immune system: hardening, normalizing the diet, regular sports training, a moderate alternation of rest and work. These measures will help only immunocompetent persons.
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Candidial meningitis is a dangerous disease in which candida fungi affect the membranes of the brain and spinal cord, cerebrospinal fluid, cerebral vessels. The disease often ends in a fatal outcome, even after healing a person remains disabled. The disease is more common in children and patients who underwent shunt neurosurgical operations.