Indications for progesterone analysis, reasons for deviations from standard indices

Blood test

Progesterone is a sex hormone that prepares a woman's body for a future pregnancy. The ovaries, placenta and adrenal glands are responsible for its production. The main functions of the substance are providing the ability to bear the baby and control menstrual bleeding.

In a man, progesterone in low concentration produces testes and adrenals. Based on it, testosterone is produced.

The analysis for progesterone involves venous blood sampling. In laboratory conditions, it is purified from cells and checked by immunochemical methods. From this article you will learn what is progesterone, how to give analysis to women, the causes of violation of norms.


  • The value of the hormone for the female body
  • Prerequisites for research
  • How to prepare for the procedure correctly
  • Blood test for progesterone: when to take?
  • Admissible hormone indices
  • Increase in the
  • Decrease of the indicator

The value of the hormone for the female body

Progesterone is considered a steroid hormone. Thanks to him, girls and women correctly undergo many life processes and have the ability to endure a baby.

A low progesterone index causes:

  1. Infertility. It is caused by the unreadiness of the uterine endometrium to interact with the fertilized egg.
  2. Sudden abortion and fetal death.

The overestimated progesterone is also harmful. It can cause:

  • Migraine.
  • Problems with vision.
  • The appearance of acne and acne.
  • Systematic decline of forces.
  • Intermenstrual bleeding.

Prerequisites for research

The doctor recommends an analysis under these circumstances:

  • With symptoms of an ectopic pregnancy.
  • Threat of miscarriage.
  • Irregular menstrual bleeding.
  • To verify the correctness of pregnancy in the early periods.
  • When planning conception.

How to prepare for the procedure correctly

How to take the progesterone test so that it shows accurate data? First, a woman should prepare for this event. For this, it must:

  1. For 14-16 days, stop taking any pharmacological agents that affect the level of progesterone, estrogen, estradiol and prolactin. These include:
  • a synthetic analogue of progesterone;
  • antifungal drugs (ketoconazole);
  • hormonal drugs (Clomifen, Mifepristone);
  • antiepileptic drugs (Depakin).
  1. For 13-14 hours before donating blood, we must exclude:
  • food;
  • alcohol;
  • power loads;
  • nicotine.

Important! The blood test for progesterone is given only on an empty stomach in the evening. If a woman can not interrupt the taking of drugs, she must submit to the laboratory or to the clinic a full list of medications taken with a dose and a pattern of use.

It is forbidden to do the analysis the day after such diagnostic procedures:

  • Endoscopic examination.
  • Ultrasonography.
  • X-ray.
  • Fluorography.

Blood test for progesterone: when to take?

Experts still can not say for sure what day of the cycle to take the progesterone test. This is due to the individual characteristics of the female body. One of the distinguishing features of this substance is that its amount in the body depends on the day of the monthly cycle and the closeness of the ovulatory phase. Therefore, the doctor chooses the time when you can take the test for the level of progesterone, for each patient separately.

How is progesterone tested for non-pregnant women? This occurs from the 20th to the 24th day of the menstrual cycle. How does an analysis for progesterone for scarce bleeding occur? In most cases, these patients should make blood sampling from the 14-18 day cycle. It is necessary to undergo two analyzes with an interval of 2-4 days.

How to take progesterone analysis for pregnant women? Future moms undergo this examination at any time.

Admissible hormone indices

When verifying the data, it is worth considering the fact that the result of the research in each laboratory may be different, so the doctor who observes the patient should decipher the analysis.

Scientists offer a table, where the permissible levels of the substance are collected.

Period Level of hormone ng / ml
Girls up to 12 years of age ,
Girls over 13 years old ,
Follicular period ,
Ovulation ,
Lutein Period , - 2,
1st trimester 19,
2nd trimester 2, - 9,
3rd trimester 4, - 42,
Menopause ,

In some research hormones, it can be indicated in nmol / l. To convert ng / ml to nmol / l, multiply the result by, 7. As a rule, the study of the hormone occurs by the in vitro method (in vitro).

Increase in the

Excess hormone levels can be provoked:

  • Multiple pregnancy. At the beginning of the second trimester of pregnancy, each fetus forms its placenta, which produces progesterone. Therefore, in the future mother of twins or triplets, the total level of the hormone is increased.
  • Slow development of the placenta. Overestimated levels of the substance during 2-6 months of pregnancy signal problems with the placenta.
  • Intermenstrual blood discharges associated with the luteal phase. A high concentration of progesterone, observed for more than 16 days, causes bleeding due to abnormal capillary development.
  • Hyperplasia of the adrenal glands. These organs also synthesize a small amount of substance. Increasing their tissue will activate the synthesis of the hormone. This pathology is most common in adult men and children under 11 years old.
  • Tumors of the ovaries and adrenal glands. An increased number of cells produces extra progesterone.
  • Choriocarcinoma. This is the name for malignant uterine formation, which is easily treated if detected early. Causes - bladder skidding, postpartum complications, ectopic pregnancy.
  • Bubble skidding. It is a broken fertilization of the egg, which leads to the accumulation of formations that look like grapes. It is characterized by the rapid development and synthesis of an abnormally large amount of progesterone.
  • Renal diseases.
  • Cirrhosis of the liver.

Decrease of the indicator

The decrease in the rate is caused by:

  • Deficiency of the yellow body. It is characterized by short-term or insufficient synthesis of the hormone. If fertilization has occurred at this time, the probability of oocyte detachment is high when the next monthly bleeding occurs.
  • The short-term luteal phase.
  • Premature release of milk in the absence of menstruation, provoked by a violation of the level of prolactin.
  • Side effects of Ampicillin, oral contraceptives, antiepileptic drugs and hormonal medications.

As a rule, to increase progesterone, a woman is appointed Dufaston. How much and how to drink it, the doctor counts depending on the individual characteristics of the patient.

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